Four options, one clinical decision.
These are the treatments the independent licensed providers we work with may consider. This page explains how they differ in form and mechanism — not which is best, because that is a judgement only a provider reviewing your health history can make.
Differences in form, not a ranking.
It is tempting to read a comparison table as a leaderboard. This one is not. Each treatment below suits a different set of circumstances, and the same option can be right for one person and inappropriate for another with a similar goal.
What actually decides the outcome of a consultation is your health history: your other medications, your past experience with GLP-1 treatment if any, contraindications, and what you and the provider are trying to achieve. A provider may also conclude that none of these is appropriate for you.
Use this page to arrive at your consultation with better questions, not with a preferred answer.
How the four options differ.
Prescription required for every option below. A licensed provider determines whether any treatment is appropriate for you.
- Most commonly considered
Compounded Semaglutide
- Form
- Weekly subcutaneous injection
- Mechanism
- GLP-1 receptor agonist
- Cadence
- Once weekly, with gradual dose titration
- A provider may weigh
- Your health history, contraindications, and how you tolerate a low starting dose.
- An alternative a provider may consider
Compounded Tirzepatide
- Form
- Weekly subcutaneous injection
- Mechanism
- Acts on both GIP and GLP-1 receptor pathways
- Cadence
- Once weekly, with gradual dose titration
- A provider may weigh
- Your health history, your goals, and how earlier treatment has gone if you have used a GLP-1 before.
- Needle-free option
Semaglutide Troche
- Form
- Sublingual troche, dissolved under the tongue
- Mechanism
- GLP-1 receptor agonist, lower systemic exposure
- Cadence
- As directed by the prescribing provider
- A provider may weigh
- Whether avoiding an injection matters to you, and whether the lower exposure suits your case.
- Supportive, not a standalone treatment
MIC+B12 Injections
- Form
- Weekly injection
- Mechanism
- Blend of methionine, inositol, choline, and vitamin B12
- Cadence
- Weekly, alongside a broader plan
- A provider may weigh
- Whether it fits alongside your wider plan. It is not a weight-loss medication on its own.
Prescription required. Compounded medications are not approved or evaluated by the FDA for safety, effectiveness, or quality, and are not equivalent to or generic versions of any branded medication. A licensed provider will determine whether treatment is appropriate for you.
What people ask when comparing
We do not rank them, and we would be misleading you if we did. These medications act through different mechanisms and are studied in different populations, and individual response varies widely. Whether any of them is appropriate for you — and which one — is a clinical decision made by the reviewing provider, not a product choice made from a page like this one.
You can tell the provider what you are hoping for, and it is useful context. It is not an instruction. The provider evaluates your health history and prescribes only what they judge appropriate, which may be something different from what you asked for, or nothing at all.
No. Those are FDA-approved, mass-manufactured branded products. The medications above are compounded — prepared by a state-licensed pharmacy against an individual prescription. Compounded medications are not FDA-approved and are not generic versions of, or equivalent to, any branded product. Ozempic and Wegovy are registered trademarks of Novo Nordisk A/S; Mounjaro and Zepbound are registered trademarks of Eli Lilly and Company. LuneRx and its partners are not affiliated with or endorsed by these companies.
A provider may revisit the plan over time based on how treatment is going, your tolerance, and your health history. Any change is a clinical decision and is made by the provider who knows your case.
That is a real outcome, and an honest one. Screening exists to catch cases where prescription treatment is not a good fit. If a provider declines to prescribe, that decision is about your safety, and we do not override it.
Not sure which questions to ask?
Start with the assessment. It collects the health history a provider needs, and the consultation is where the comparison actually gets made.
See if you qualify.
A two-minute assessment is the first step. An independent licensed provider takes it from there.
Get StartedNo commitment required to complete the assessment.